Retinal nerve fiber layer thickness, as measured by Stratus OCT, varies significantly with age, ethnicity, axial length, and optic disc area. These variables may need to be taken into account when evaluating patients for diagnosis and follow-up of glaucoma, particularly at the lower boundary of the normal range.
Example of retinal nerve fiber layer (RNFL) analysis with spectral-domain optical coherence tomography (SD-OCT). Top: The right eye shows diffuse RNFL thinning on SD-OCT (A), which is consistent with the neuroretinal rim thinning and enlarged cup seen in the photographs of the optic nerve head (B) and with the visual field loss that is evident on standard automated perimetry (SAP) (C).
Although a critical value of RNFL thickness has been proposed, there was a considerable overlap in OCT measurements between MS and NMO, limiting the role of OCT to differentiate the two conditions on an individual basis. Prognostic value and future developments of OCT in MS.
This represents the thickness of the RNFL across the entire scan. Thousands of points are measured in a single OCT scan and these are plotted on a map using colors to represent thickness value. Warm colors, such as red and white, are relatively thicker areas of the RNFL, while cooler colors, such as.
Optical coherence tomography (OCT) provides real-time and cross-sectional measurements of various layers of the retina, including quantitative and objective assessments of RNFL thickness. OCT employs the principles of low-coherence interferometry and is analogous to ultrasound B-mode imaging but uses light instead of sound to acquire images of ocular structures.
Although OCT analyses of macular and optic nerve neuroretinal rim thickness have become increasingly popular in recent years, RNFL analysis has been the benchmark of OCT imaging in glaucoma since its inception. 2 RNFL analysis provides an alternative to the visual inspection of the optic nerve neuroretinal rim as well as a quantitative estimation of retinal ganglion cell axonal loss.
Retinal Nerve Fiber Layer (RNFL) This area represents the axons of the ganglion cells within the innermost aspect of the retina. During the OCT scan acquisition process, the thickness of the RNFL is calculated from thousands of locations.
Cirrus RNFL and ONH Analysis Elements OCT en face fundus image shows boundaries of the cup and disc and the RNFL calculation circle. The integrated RNFL thickness deviation map shows deviation from normal RNFL thickness map also displays cup and disc mask Optic Nerve Head calculations are presented in a combined report with RNFL thickness data. Key.
With the use of asymmetry analysis, macular thickness is a measurement that can be used for the detection and progression of glaucoma. Some artifacts seen on retinal nerve fiber layer (rNFL) scans may be overcome by macular SD-OCT imaging.
Retinal Nerve Fiber Layer Analysis by OCT RNFL is measured in the peripapilary region with circular scans of 3.4 mm diameter centered around the optic nerve head Measurements of RNFL thickness are shown in a TSNIT orientation and are compared to age-matched controlled individuals.
The changes in average cup-to-disc ratio are analyzed, and RNFL thickness profiles over time and on a specific day are provided analyzed for change over time. Another nice feature is a table of numerical values of the parameters for each visit with significant changes emphasized.
The Stratus OCT RNFL thickness average analysis is shown in Fig. 3a for OS. This analysis displays the RNFL thickness profile for the study eye (black line), superimposed on the characteristic double hump profile pattern resulted from the internal normative database. In this example, the RNFL is clearly thinner in the inferior region.
In contrast, use of OCT GPA detected progression in 36 eyes (13.2%) of 34 patients. Twenty-three eyes progressed by RNFL thickness mapping, nine by RNFL thickness profiles, and 16 by average RNFL thickness assessment; five eyes were detected by all three approaches. Of the three strategies, RNFL thickness mapping most frequently detected.
Effect Of Myopia On Measuring Peripapillary Retinal Nerve Fiber Layer Thickness ABSTRACT Settings: Faculty of Medicine, Alexandria University, Egypt. Purpose: To assess the influence of axial length (AL) and refractive status of the eye on retinal nerve fiber layer (RNFL) thickness in myopic eyes measured by spectral domain optical coherence tomography (OCT).
The RNFL thickness profile, with a spatial resolution of 256 points, is the machine-averaged value for the 3 scans. Only scans with a signal greater than 5 were used. The 256-point RNFL thickness profiles were exported for further analysis. The profile for the scan in Fig. 1B is shown in Fig. 1C.Read 13 answers by scientists with 2 recommendations from their colleagues to the question asked by Syed Hasnain on Apr 13, 2014.The retinal nerve fiber layer (RNFL) or nerve fiber layer, stratum opticum, is formed by the expansion of the fibers of the optic nerve; it is thickest near the optic disc, gradually diminishing toward the ora serrata. As the nerve fibers pass through the lamina cribrosa sclerae they lose their medullary sheaths and are continued onward through the choroid and retina as simple axis-cylinders.